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Protective Effect of Bene (Pistacia Atlantica) on Busulfan-Induced Renal-Liver Injury in Laboratory Mice
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H Norasteh    , Sh Mohammadi * , M Nikravesh , Sh Taraz Jamshidi |
| 1. Department of Anatomy and Cell Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, I.R.Iran , mohammadish@mums.ac.ir |
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Abstract: (12368 Views) |
BACKGROUND AND OBJECTIVE: Busulfan is a chemotherapy drug that has side effects such as hepatic and renal injury. Pistacia atlantica from the family Anacardiaceae has a potent antioxidant agent due to phenolic compounds. The purpose of this study was to investigate the effects of Pistacia atlantica on histopathology and liver and kidney function indicators in busulfan-induced liver and kidney injuries in adult mice.
METHODS: A total of 28 BALB/c mice were randomly divided into four groups (control, busulfan, bene and bene+busulfan). The busulfan group received 10 mg/kg busulfan as a single dose and intraperitoneally. The bene group received plate containing 10% of bene for 35 days. The bene+busulfan group received 10 mg/kg busulfan+10% bene. Then, liver enzymes alanine amino transferase, aspartate amino transferase, urea, creatinine and histopathology of liver and kidney investigated.
FINDINGS: The mean urea (P= 0.009) and creatinine level (P= 0.02) in the busulfan group was 55.2±4.23 and 0.8±0.11 mg/dl that it was significantly higher than the bene + busulfan. A significant decrease in ALT level in the bene + busulfan group compared to the busulfan treated group (P= 0.03). In the bene treated group steatosis, necrosis and fibrosis in the liver parenchyma and glomerular sclerosis, inflammation and tubular atrophy in kidney tissue, was not observed.
CONCLUSION: The results of present study indicated that administration of 10% bene for 35 days improved histopathology of kidney and liver as well as functional index of liver and kidney after renal-liver injury. |
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| Keywords: Pistacia atlantica, wild pistacia, mouse, liver, kidney, busulfan. |
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Full-Text [PDF 338 kb]
(2827 Downloads)
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Type of Study: Case-Control |
Subject:
Descriptive Sciences
Received: 2018/12/4 | Accepted: 2019/11/3 | Published: 2019/12/25
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