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The Effect of Silver Diamine Fluoride with or without Glutathione and Potassium Iodide on Discoloration, Fluoride Release, and Microhardness of Primary Teeth
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M Khataminia    , S Tehrani * , Sh Taravati |
| 1.Department of Pediatric Dentistry, School of Dentistry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, I.R.Iran. , s.tehrani1993@gmail.com |
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Abstract: (96 Views) |
Background and Objective: Silver diamine fluoride (SDF) is a minimally invasive alternative to conventional restorative methods. Despite proven benefits, it causes discoloration of teeth and gingiva. The present study was conducted to investigate the effect of silver diamine fluoride (SDF) with or without glutathione (GSH) and potassium iodide (KI) on discoloration, fluoride release, and microhardness of primary teeth.
Methods: This in vitro study was conducted on 51 human anterior primary teeth extracted due to trauma or becoming loose. After artificial induction of dentin demineralization, the teeth were randomly assigned to 3 groups of 17: SDF, SDF+KI, and SDF+20%GSH. The color change (ΔE) was measured using a spectrophotometer, dentin microhardness was measured using a Vickers hardness tester, and the concentration of fluoride released was measured using a potentiometer immediately after treatment and also after one and three months of immersion in artificial saliva.
Findings: The mean dentin microhardness in all three groups decreased significantly over time. In the SFD group, it decreased from 25.17±4.69 to 21.09±4.12, in the SFD+KI group from 22.35±3.41 to 18.62±2.19, and in the SFD+GLU group from 18.35±2.21 to 15.65±2.61 after three months (p<0.001). The mean dentin microhardness in the SDF group was significantly higher than in the other groups at all time points (p<0.001). Fluoride release in all three groups increased significantly over time (p<0.001). Fluoride release in the SDF+KI group was significantly higher than in the other two groups at all time points (2.41±0.47) (p<0.001). The color change (ΔE) in the SDF+KI group was significantly greater than that in the SDF group three months after treatment compared to immediately after treatment (p<0.01).
Conclusion: The results of the study showed that SDF alone produced the highest microhardness, while SDF+KI showed the highest fluoride release and the greatest color change three months after treatment. |
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| Keywords: Silver Diamine Fluoride, Hardness, Tooth Discoloration, Fluorides. |
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Full-Text [PDF 342 kb]
(16 Downloads)
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Type of Study: Research |
Subject:
Dentistry (Radiology)
Received: 2024/12/3 | Accepted: 2025/01/6 | Published: 2025/12/17
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