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The Effect of Iranian Propolis on Oral Mucositis Induced by X-Ray Irradiation in Rats
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M Rouhi    , M Motallebnejad , HR Nouri , M Seyedmajidi , D Moslemi , A Bijani , S Kazemi , F Asgharpour * |
| 4.Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran. , f_asgharpour@yahoo.com |
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Abstract: (154 Views) |
Background and Objective: Ionizing radiation has destructive effects on the oral mucosa during head and neck cancer treatment, the most common complication of which is oral mucositis. The present study was conducted to investigate the effect of Iranian propolis as a natural substance on the prevention and treatment of radiotherapy-induced oral mucositis in rats.
Methods: In this experimental study, 48 adult Wistar rats were randomly divided into 4 groups receiving normal saline (C), propolis 400 mg/kg (P), propolis 400 mg/kg + X-ray irradiation (PR), and normal saline + X-ray irradiation (SR). PR and SR groups were exposed to 15 Gy of X-rays. Rats were injected intraperitoneally with propolis every day (P and PR groups), and the severity of oral mucositis was recorded after irradiation using the Parkins scale until day 10. Histopathological samples were prepared from the middle third of the tongue of the rats on day 5 and 10 and were then examined.
Findings: The severity of mucositis increased from day 1 to day 10 in each group separately and was significantly lower in the PR group than the SR group on days 4 and 6 to 10 (p<0.001). The changes in the histopathological appearance of the samples in the irradiated groups were more severe than in the non-irradiated groups (p<0.001). Furthermore, the SR group showed the lowest body weight compared to the other groups on day 10 (p<0.001).
Conclusion: According to the results of this study, it seems that Iranian propolis plays an effective role in the treatment and control of radiotherapy-induced oral mucositis and is recommended as a suitable medicine to relieve the symptoms of mucositis and reduce oral ulcers. |
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| Keywords: X-Ray, Propolis, Mouth, Mucositis. |
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Full-Text [PDF 479 kb]
(14 Downloads)
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Type of Study: Experimental |
Subject:
Dentistry (Oral Diseases)
Received: 2024/09/7 | Accepted: 2025/01/20 | Published: 2025/12/17
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