|
An Evaluation of OGG1 rs1052133C>G Polymorphism in Thyroid Cancer Susceptibility in the Northwestern Region of Iran
|
N Pouladi *    , S Didevar Tabrizi , R Ravanbakhsh |
| 1.Department of Cellular and Molecular Biology, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, I.R.Iran. , srna52@gmail.com |
|
|
Abstract: (369 Views) |
Background and Objective: Thyroid cancer is the most common endocrine malignancy in the world. Genetic studies have focused on the role of polymorphisms in genes involved in DNA repair and the risk of cancer susceptibility. The OGG1 gene encodes a key enzyme in the DNA repair pathway. Studies show that the single nucleotide polymorphism rs1052133C>G is associated with an increased risk of developing various types of cancer. The aim of this study is to investigate the association between the aforementioned polymorphism and the risk of thyroid cancer susceptibility in the northwestern region of Iran.
Methods: In this case-control study, 104 patients with thyroid cancer (thyroid cancer tissue confirmed by a pathologist) and 166 controls (healthy individuals with no history of cancer in themselves or their first-degree relatives) were selected. Blood samples were collected and their DNA was extracted by the saturated salt method. OGG1 genotypes were identified and analyzed using the Tetra-ARMS PCR method.
Findings: In this study, the frequencies of CC, CG, and GG genotypes in the patient group were 53.84%, 38.46%, and 7.69%, respectively, and in the control group, 51.2%, 41.56%, and 7.22%, respectively. The frequencies of C and G alleles in the patient group were 73.06% and 26.92%, respectively, and in the control group, 71.98% and 28.01%, respectively. Based on the results obtained, no significant difference was observed between the patient group and the control group in different inheritance models.
Conclusion: The results of the study showed that there is no association between the rs1052133C>G polymorphism of the OGG1 gene and the risk of thyroid cancer in the northwestern region of Iran.
|
|
| Keywords: Polymorphism, OGG1 Gene, Thyroid Cancer, rs1052133. |
|
|
Full-Text [PDF 417 kb]
(59 Downloads)
|
Type of Study: Case-Control |
Subject:
Genetics, Cell and Molecular Biology
Received: 2023/12/25 | Accepted: 2024/08/6 | Published: 2025/07/29
|
|
|
|
|
|
|
| Send email to the article author |
|
|
