fa ارتباط بین داروهای کاهنده فشارخون بالا و سقوط در سالمندان شهر امیرکلا داخلی Internal همگروهی Cohort <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:11pt"><span style="line-height:16.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><b><span lang="AR-SA">سابقه<b> </b>و هدف: </span></b><span lang="FA">شناخت</span> <span lang="FA">عوامل</span> <span lang="FA">موثر</span> <span lang="FA">در</span> <span lang="FA">ایجاد</span> <span lang="FA">سقوط،</span> <span lang="FA">نقش</span> <span lang="FA">مهمی</span> <span lang="FA">در</span> <span lang="FA">کاهش</span> <span lang="FA">مشکل و</span> <span lang="FA">هزینه</span> <span lang="FA">های مربوط</span> <span lang="FA">به</span> <span lang="FA">درمان</span> <span lang="FA">آن ایفا</span> <span lang="FA">می</span> <span lang="FA">کند. با توجه به متناقض بودن داده ها در مورد استفاده از داروهای کاهنده فشارخون بالا و سقوط در افراد سالمند، این</span> <span lang="FA">مطالعه</span> <span lang="FA">با</span> <span lang="FA">هدف</span> <span lang="FA">تعیین</span> <span lang="FA">ارتباط</span> <span lang="FA">بین</span> <span lang="FA">مصرف داروهای</span> <span lang="FA">کاهنده فشار</span> <span lang="FA">خون</span> <span lang="FA">بالاو سقوط</span> <span lang="FA">در</span> <span lang="FA">سالمندان</span> <span lang="FA">انجام</span> <span lang="FA">شد</span><span lang="AR-SA">.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:16.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><b><span lang="AR-SA">مواد و روش&shy; ها: </span></b><span lang="FA">این</span> <span lang="FA">مطالعه</span> <span lang="FA">مقطعی بخشی</span> <span lang="FA">از</span> <span lang="FA">فاز</span> <span lang="FA">اول</span> <span lang="FA">کوهورت</span> <span lang="FA">سالمندان</span> <span lang="FA">شهر</span> <span lang="FA">امیرکلا</span> <span lang="FA">بوده</span> <span lang="FA">که</span> <span lang="FA">بر</span> <span lang="FA">روی</span> <span lang="FA">سه</span> <span lang="FA">گروه 250 نفری</span> <span lang="FA">متشکل</span> <span lang="FA">از</span> <span lang="FA">سالمندان سالم،</span> <span lang="FA">مبتلایان</span> <span lang="FA">به پرفشاری</span> <span lang="FA">خون با و بدون مصرف</span> <span lang="FA">داروی کاهنده فشار</span> <span lang="FA">خون،</span> <span lang="FA">انجام</span> <span lang="FA">شد</span>.<span lang="FA"> داروهای</span> <span lang="FA">کاهنده فشار</span> <span lang="FA">خون در 6 گروه</span> <span lang="FA">بر اساس مکانیسم اثر تقسیم</span> <span lang="FA">شدند. متغیرهای سن، جنس، شاخص توده بدنی، فعالیت فیزیکی، دیابت، تعداد داروها، علائم افسردگی، وضعیت شناختی، تعداد بیماری همراه</span> <span lang="FA">و نیز فراوانی</span> <span lang="FA">سقوط</span> <span lang="FA">در یک سال قبل از شروع مطالعه و در پیگیری شش ماهه با پرسش از افراد سالمند در</span> <span lang="FA">سه</span> <span lang="FA">گروه</span> <span lang="FA">و</span> <span lang="FA">نیز</span> <span lang="FA">در دسته</span> <span lang="FA">های مختلف</span> <span lang="FA">داروهای</span> <span lang="FA">کاهنده فشار</span> <span lang="FA">خون</span> <span lang="FA">مورد</span> <span lang="FA">بررسی</span> <span lang="FA">و مقایسه قرار</span> <span lang="FA">گرفت</span><span lang="AR-SA">.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:16.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><b><span lang="AR-SA">یافته‌ها: </span></b><span lang="AR-SA">از کل سالمندان مورد مطالعه، 126 نفر (16/8%) طی 12 ماه گذشته و 36 نفر (4/8%)&nbsp; طی پیگیری شش ماهه دچار سقوط شدند. ارتباط معنی داری بین سقوط و مصرف داروی کاهنده فشار خون و نیز بین مصرف کلاس های مختلف داروهای کاهنده فشار خون با سقوط پیدا نشد. متغیرهایی همچون علائم افسردگی (2/057&nbsp;</span><span lang="AR-SA">=</span><span dir="LTR">OR</span><span lang="FA">، 0/001=</span><span dir="LTR">p</span><span lang="FA">)، تعداد بیماری های همراه (0/189</span><span lang="FA">=</span><span dir="LTR">OR</span><span lang="FA">، 0/006</span><span lang="FA">=</span><span dir="LTR">p</span><span lang="FA">) و سن بالاتر (1/033</span><span lang="FA">=</span><span dir="LTR">OR</span><span lang="FA">، 0/040</span><span lang="FA">=</span><span dir="LTR">p</span><span lang="FA">) نقش موثری در ایجاد سقوط داشتند.</span></span></span></span></span><br> <b><span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span style="line-height:107%">نتیجه‌گیری: </span></span></b><span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span style="line-height:107%">نتایج مطالعه نشان داد که </span></span><span dir="RTL" lang="FA" style="font-size:11.0pt"><span style="line-height:107%">استفاده از داروهای کاهنده</span></span> <span dir="RTL" lang="FA" style="font-size:11.0pt"><span style="line-height:107%">فشار</span></span> <span dir="RTL" lang="FA" style="font-size:11.0pt"><span style="line-height:107%">خون و</span></span> <span dir="RTL" lang="FA" style="font-size:11.0pt"><span style="line-height:107%">کلاس های مختلف آن با افزایش فراوانی</span></span> <span dir="RTL" lang="FA" style="font-size:11.0pt"><span style="line-height:107%">سقوط</span></span> <span dir="RTL" lang="FA" style="font-size:11.0pt"><span style="line-height:107%">در</span></span> <span dir="RTL" lang="FA" style="font-size:11.0pt"><span style="line-height:107%">سالمندان همراه نمی باشد</span></span><span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span style="line-height:107%">.<b> </b></span></span></span></div> <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:11pt"><span style="line-height:14.0pt"><b><span style="font-size:10.0pt">Background and Objective:</span></b><span style="font-size:10.0pt"> Being familiar with the factors that are effective in causing falls plays an important role in reducing the issues and costs related to its treatment. Considering the contradictory results about the use of antihypertensive drugs and falls in older adults, the present study was conducted to determine the association between the use of antihypertensive drugs and falls in older adults.</span></span></span><br> <span style="font-size:11pt"><span style="line-height:14.0pt"><b><span style="font-size:10.0pt">Methods:</span></b><span style="font-size:10.0pt"> This cross-sectional study was a part of the first phase of Amirkola Health and Ageing Project (AHAP), which was conducted on three groups of 250 people including healthy elderly, and hypertensive patients with and without taking antihypertensive drugs. Antihypertensive drugs were divided into 6 groups based on the mechanism of action. The variables of age, gender, body mass index, physical activity, diabetes, number of medications, depression symptoms, cognitive status, number of comorbidities, and the frequency of falls during one year before the beginning of the study and during the six-month follow-up were evaluated and compared in different categories of antihypertensive drugs by asking older adults in the three groups.</span></span></span><br> <span style="font-size:11pt"><span style="line-height:14.0pt"><b><span style="font-size:10.0pt">Findings:</span></b><span style="font-size:10.0pt"> Out of all studied older adults, 126 people (16.8%) fell during the last 12 months and 36 people (4.8%) fell during the six-month follow-up. No significant relationship was found between falls and the use of antihypertensive drugs, and between the use of different classes of antihypertensive drugs and falls. Variables such as depressive symptoms (OR=2.057, p=0.001), number of comorbidities (OR=0.189, p=0.006) and older age (OR=1.033, p=0.040) had an effective role in causing falls.</span></span></span><br> <b><span style="font-size:10.0pt"><span style="line-height:107%">Conclusion:</span></span></b><span style="font-size:10.0pt"><span style="line-height:107%"> The results of the study showed that the use of antihypertensive drugs and their different classes was not associated with the increase in the frequency of falls in older adults.</span></span></span></div> سقوط, عوامل کاهنده فشار خون, عوامل خطر, سالمندان. Falls, Antihypertensive Agents, Risk Factors, Older Adults. 472 481 http://jbums.org/browse.php?a_code=A-10-599-7&slc_lang=fa&sid=1 M Kamali مژده کمالی mojdekamali1374@gmail.com 2050645759 100319475328460055167 No 1.Student Research Committee, Babol University of Medical Sciences, Babol, I.R.Iran. 1. کمیته تحقیقات دانشجویی، دانشگاه علوم پزشکی بابل، بابل، ایران SR Hosseini سیدرضا حسینی hosseinirezaseyed@gmail.com 2141206472 100319475328460055168 Yes 2.Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran. 2. مرکز تحقیقات عوامل اجتماعی موثر بر سلامت، پژوهشکده سلامت، دانشگاه علوم پزشکی بابل، بابل، ایران R Ghadimi رضا قدیمی rezaghadimi@yahoo.com 100319475328460055169 100319475328460055169 No 2.Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran. 2. مرکز تحقیقات عوامل اجتماعی موثر بر سلامت، پژوهشکده سلامت، دانشگاه علوم پزشکی بابل، بابل، ایران A Rahimi آتنا رحیمی atena.rahimi@yahoo.com 100319475328460055170 100319475328460055170 No 3.Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran. 3. مرکز تحقیقات سلولی و مولکولی، پژوهشکده سلامت، دانشگاه علوم پزشکی بابل، بابل، ایران A Bijani علی بیژنی 100319475328460055171 100319475328460055171 No 2.Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran. 2. مرکز تحقیقات عوامل اجتماعی موثر بر سلامت، پژوهشکده سلامت، دانشگاه علوم پزشکی بابل، بابل، ایران