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The Effect of Insect Extract on Liver Tissue and Function in Diabetic Mice
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R Ali Rahmat *    , M Abdul Azeez Shafeeq , J Jouda |
| 1.Department of Oral Pathology, College of Dentistry, Mustansiriyah University, Baghdad, Iraq. , rawaaali90@uomustansiriyah.edu.iq |
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Abstract: (36 Views) |
Background and Objective: The world is currently turning to treating diseases with alternative medicine to reduce the effects of chemical drugs. This study's objective is to evaluate the physiological and histological changes that take place in the liver of STZ-induced diabetic mice and then evaluate their treatment with Gryllus bimaculatus (GB) extract compared to Metformin.
Methods: This experimental study was conducted on 60 male albino mice weighing 20 to 27 g. 40 mice randomly received 50 μg/kg body weight streptozocin (STZ) through intraperitoneal (IP) administration, whereas 20 mice were not injected and were designated as the control group. Diabetic mice were divided into four groups (n=10): high concentration of insect extract group (HEG), low concentration of insect extract group (LEG), Metformin group (MG), and without treatment as positive control group (+CG). The healthy group was also divided into two groups: one group consumed insect extract (ECG) and the other one served as negative control group (-CG). After one month, mice were scarified and their blood was collected and used to determine fasting blood glucose (FBG), insulin (INS), alkaline phosphatase (ALP) and alanine transaminase (ALT).
Findings: FBG, INS, ALP and ALT in experimental groups showed a significant difference compared to the control group and Metformin group. The LEG group exhibited the closest value of all above parameters to control group (80.5±5.2, 7.2±3.6, 53.8±7.4 and 37.0±5.9 U/L, respectively). This was also shown in histological examination of liver sections in which liver of LEG group was normal compared to MG group, which still had fatty changes of liver cells.
Conclusion: The results of the study showed that low concentration of insect extract could be a suitable treatment for DM and liver disorder compared to metformin.
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Article number: e24 |
| Keywords: Diabetes Mellitus, Alkaline Phosphatase, Alanine Transaminase, Insect Extract. |
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Full-Text [PDF 896 kb]
(14 Downloads)
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Type of Study: Research |
Subject:
Dentistry (Oral Diseases)
Received: 2025/01/6 | Accepted: 2025/03/16 | Published: 2026/07/1
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