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The Predictive Role of Some Immunological Markers and Testosterone in Iraqi Male Patients with Rheumatoid Arthritis
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BH Hameedi *   , AA AL- Naqeeb , SI Bajilan , SG Turki |
| 1.Department of Basic Science, College of Nursing, University of Baghdad, Baghdad, Iraq. , banhh@conursing.uobaghdad.edu.iq |
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Abstract: (20 Views) |
Background and Objective: Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammatory arthritis and extra-articular involvement. Roles of interleukin-18 (IL-18), Galectin-1 (Gal-1), and testosterone markers in pathogenesis RA are unknown. Therefore, the present study was conducted to detect these markers in patients with RA.
Methods: This case-control study was conducted on 100 men aged 39 - 80 years. 60 blood samples were collected from patients who visited the teaching hospital of Baqubah, Diyala governorate from Nov. 2022 to Jan. 2023. RA patients were diagnosis by the consultant doctor in advisory units based on symptoms and laboratories tests (CRP, ACCP, ESR, RF). 40 blood samples were collected from healthy individuals (control group). Levels of CRP and RF markers in samples were evaluated by RosheCobas e411, while Galectin-1, IL-18, ACCP, and testosterone were measured by (ELISA) (CUSABIO Company).
Findings: The present results revealed that the age groups of 40-49 and 50-59 scored the highest (31.7% and 28.3%) compared to the age groups of <40 and >60 years, which scored the least (11.7% and 10.0%). The positivity of rheumatoid factor (RF) and C-reactive protein (CRP) markers scored the highest percentage in patients (70.0% and 78.3%) compared to healthy subjects (12.5% and 20.0%). Gal-1 and testosterone levels were low in patients (5.23±2.07 and 176.20±42.41) compared to healthy subjects (22.73±8.42 and 341.30±64.59). In contrast, levels of IL-18 and ACCP markers were high in patients (323.70±40.90 and 34.88±6.75) compared to healthy subjects (169.58±35.61 and 5.55±2.39). The differences between age, RF, CRP, IL-18, ACCP, Gal-1 and testosterone and study groups were significant (p<0.05).
Conclusion: According to the results of the present study, disease severity increased with age. Galectin-1 and interleukin-18 are markers that are known to be prognostic in the screening of patients with RA. Testosterone is good marker in screening RA males with sexual dysfunction.
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| Keywords: Rheumatoid Arthritis, Galectin-1, IL-18, and Testosterone. RF, CRP, ACCP. |
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Type of Study: Research |
Subject:
Nursing
Received: 2024/06/10 | Accepted: 2024/09/14
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| Send email to the article author |
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