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Investigation of the Protective Effects of Carvacrol on Cholemic Nephropathy in Cholestatic Rats
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SMG Hosseini    , A Ghafarian Behrman , I Salimi Kia , M Mohammadi , F Asadi Dolatabad , H Mohammadi * |
| 3.Razi Herbal Medicine Research Center, Lorestan University of Medical Sciences, Khorramabad, I.R.Iran. , hamidrezamohammadi65@yahoo.com |
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Abstract: (487 Views) |
Background and Objective: Kidney is one of the organs that is damaged after liver cirrhosis. This damage to kidney tissue following liver tissue failure is called cholemic nephropathy. Since one of the main mechanisms in the development of cholemic nephropathy is oxidative stress and reduced antioxidant reserves, the present study was conducted to investigate the protective effect of carvacrol as an antioxidant on cholemic nephropathy in cholestatic rats.
Methods: This experimental study was conducted on 40 male Wistar rats in 5 groups of 8. Cholestasis was induced by bile duct ligation (BDL). Animals received different doses of carvacrol (25, 50, 100 mg/kg) via gavage. At the end of the period and after carvacrol administration, serum biochemical factors such as creatinine (Cr) and blood urea nitrogen (BUN) and urinary factors including glucose and protein, levels of reactive oxygen species (ROS), lipid peroxidation (MDA) as well as the activities of antioxidant enzymes such as superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) were evaluated in kidney tissue of cholestatic rats.
Findings: Serum levels of BUN and Cr in cholestatic rats were (59±2, 0.8), respectively, which were increased compared to the control groups (17±2, 0.18) (p=0.002). Serum levels of oxidative stress indicators MAD, ROS in cholestatic rats were (17±1, 154109), respectively, which were significantly higher than the control groups (5±1, 37124±11) (p=0.007). Moreover, the activities of antioxidant enzymes (CAT, SOD, GPx) in cholestatic rats were (200±11, 19±3, 20±1), respectively, which were significantly decreased compared to the control groups (600±34, 64±2, 43±1) (p=0.001).
Conclusion: The results of the study showed that administering carvacrol can reduce oxidative stress caused by bile duct ligation in the kidneys.
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| Keywords: Oxidative Stress, Bile Duct Ligation, Cholemic Nephropathy, Carvacrol. |
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Full-Text [PDF 401 kb]
(169 Downloads)
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Type of Study: Experimental |
Subject:
Pharmacology
Received: 2024/06/27 | Accepted: 2024/10/12 | Published: 2025/10/21
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